m6A (N6-methyladenosine) is the most common post-transcriptional modification of eukaryotic mRNAs, accounting for 80% of RNA methylation modifications. As early as the 1970s, m6A modifications have been identified in eukaryotic mRNA and lncRNA. The m6A genes consist of three groups, including writers, readers (IYT521-B homolog [YTH]) and erasers (alkylation repair protein-B [AlkB]).
  Readers we were identified by going through 'PF04146', and a total of 80 functional genes were obtained.Members of the YTH family are highly conserved and contain an aromatic pocket YTH structure for base recognition of N6-methyladenosine.The proteins of the YTH structural domain can be divided into two distinct subfamilies.YTHDF and YTHDC.The YTHDF subfamily proteins bind mainly to all N6-methyladenosine sites in mRNA, while YTHDC binds only to certain nuclear enrichment sites. Click here to download the full Readers gene list.